Inhibitors of prenyl-protein transferase

A compound of the formula D:

• wherein:
• R1b and R1c are independently selected from hydrogen or C1-C6 alkyl;
• R1d is selected from:
• a) hydrogen,
• b) C1-C6 alkyl;
• R1e is independently selected from:
• a) hydrogen,
• b) aryl, heterocycle, C3-C10 cycloalkyl, R10O—, —N(R10)2 or C2-C6 alkenyl, and
• c) C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl, unsubstituted or substituted by aryl, heterocycle, C3-C10 cycloalkyl, C2-C6 alkenyl, R10O—, or —N(R10)2;
• R4 is C1-4 alkyl;
• R6 and R7 are independently selected from:
• a) hydrogen,
• b) C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, R10C(O)— or R10OC(O)— and
• c) C1-C6 alkyl substituted by C1-C6 perfluoroalkyl, R10O—, R10C(O)NR10—, (R10)2N—C(NR10)—, R10C(O)—, R10OC(O)—, —N(R10)2, or R11OC(O)NR10—;
• R8 is independently selected from:
• a) hydrogen,
• b) unsubstituted or substituted aryl, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 perfluoroalkyl, F, Cl, R12O—, R10C(O)NR10—, CN, NO2, (R10)2N—C(NR10)—, R10C(O)—, —N(R10)2, or R11OC(O)NR10—, and
• c) C1-C6 alkyl substituted by unsubstituted or substituted aryl, C1-C6 perfluoroalkyl, R10O—, R10C(O)NR10—, (R10)2N—C(NR10)—, R10C(O)—, —N(R10)2, or R11OC(O)NR10—;
• R9a is selected from hydrogen, C1-C6 alkyl and C1-C6 perfluoroalkyl;
• R10 and R12 are independently selected from hydrogen, C1-C6 alkyl, benzyl and unsubstituted or substituted aryl;
• R11 is independently selected from C1-C6 alkyl and unsubstituted or substituted aryl;
• A1 is selected from a bond, —N(R10)—, S(O)m and O;
• X is selected from a bond, —C(O)— and S(O)2;
• Y is selected from:
• —C(O)—, —C(O)NR10—, —NR10C(O)—, —NR10C(O)NR10—, O, —N(R10)—, —S(O)2N(R10)—, —N(R10)S(O)2—, and S(O)m;
• Z1 is selected from unsubstituted or substituted phenyl or unsubstituted or substituted naphthyl, wherein the substituted phenyl or substituted naphthyl is substituted with one or two of:
• 1) C1-4 alkyl, unsubstituted or substituted with:
• a) C1-4 alkoxy,
• b) NR6R7,
• c) C3-6 cycloalkyl,
• d) aryl or heterocycle,
• e) HO,
• f) —S(O)mR4, or
• g) —C(O)NR6R7,
• 2) phenyl, pyridyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, thienyl, furyl or isothiazolyl,
• 3) halogen,
• 4) OR6,
• 5) NR6R7,
• 6) CN,
• 7) NO2,
• 8) CF3,
• 9) —S(O)mR4,
• 10) —C(O)NR6R7, or
• 11) C3-C6 cycloalkyl;
• m is 0, 1 or 2;
• n is 0 or 1;
• r is 0 to 5;
• s is independently 0, 1, 2 or 3;
• and
• t is 1, 2, 3 or 4;
• or a pharmaceutically acceptable salt or stereoisomer thereof.