Electrospraying for mass fabrication of chips and libraries
AssigneeNew York University
InventorsVictor Morozov, Tamara Ya. Morozova
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Abstract
A method of fabricating deposits of non-volatile substances, including biomacromolecules, in the form of spots and filing on a substrate surface by electrospray, where the deposits are used to determine the interaction of the deposited non-volatile substances to other substances. Also included in this method is the mass fabrication on a single chip of an array of single and multicomponent microsamples.
Claims43
A method for fabricating a deposit of a non-volatile biologically functional and/or biologically active substance on a substrate, comprising:
- electrospraying a solution of said non-volatile biologically functional and/or biologically active substance under a voltage effective to atomize said solution without destroying the functional properties of the non-volatile biologically functional and/or biologically active substance;
- and
- depositing the electrosprayed substance in the form of dry deposit on contact with a surface of the substrate as the biologically functional and/or biologically active substance.
The method in accordance with 1, wherein the electrosprayed solution further comprises a stabilizer.
A method for fabricating a deposit of a non-volatile biologically functional and/or biologically active substance on a substrate, comprising:
- electrospraying a solution of said non-volatile biologically functional and/or biologically active substance under conditions which prevent corona discharge with partial or complete evaporation of solvent;
- and
- depositing the electrosprayed biologically functional and/or biologically active substance on a surface of the substrate as a dry charged residue or as a highly concentrated solution.
Dependencies are inferred from the claim text.