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US 6,348,469 B1Granted
Solid compositions containing glipizide and polyethylene oxide
AssigneePharma Pass LLC
InventorPawan Seth
Life of this patent
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Abstract
The invention provides a solid composition comprising glipizide which is not in an amorphous form; polyethylene oxide; the balance consisting of conventional additives; and a functional coating; exhibiting a dissolution profile such that after 4 hours, from 10 to 30% of the glipizide is released, after 8 hours, from 40 to 60% of the glipizide is released, after 12 hours, from 80 to 100% of the glipizide is released.
Claims8
A solid composition comprising, by weight based on the total weight of the composition:
- (a) from 1 to 15% of glipizide which is not in an amorphous form;
- (b) from 60 to 80% of polyethylene oxide;
- (c) the balance consisting of conventional additives, excluding basic components;
- and
- (d) a functional coating comprising, based on the weight of the coating, from 30 to 80% of a gastroresistant polymer and from 10 to 40% of a hydrophilic silicon dioxide;
- exhibiting a dissolution profile such that after 4 hours, from 10 to 30% of the glipizide is released, after 8 hours, from 40 to 60% of the glipizide is released, after 12 hours, from 80 to 100% of the glipizide is released.
3 more elements
A solid composition comprising, by weight based on the total weight of the composition:
- (a) from 1 to 15% of glipizide which is not in an amorphous form;
- (b) from 60 to 80% of polyethylene oxide;
- (c) the balance consisting of conventional additives, excluding basic components;
- and
- (d) a functional coating comprising, based on the weight of the coating, from 30 to 80% of a gastroresistant polymer comprised of uncured poly(meth)acrylic acid;
- from 10 to 40% of a hydrophilic silicon dioxide and from 5 to 30% of polyethyleneglycol;
- exhibiting a dissolution profile such that after 4 hours, from 10 to 30% of the glipizide is released, after 8 hours, from 40 to 60% of the glipizide is released, after 12 hours, from 80 to 100% of the glipizide is released.
4 more elements
Dependencies are inferred from the claim text.