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AssigneeThe UAB Research Foundation
InventorsDe-chu C. Tang, Donald H. Marks, David T. Curiel, Zhongkai Shi, Kent Rigby van Kampen
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Disclosed and claimed are methods of non-invasive genetic immunization in an animal and/or methods of inducing a systemic immune or therapeutic response in an animal, products therefrom and uses for the methods and products therefrom. The methods can include contacting skin of the animal with a vector in an amount effective to induce the systemic immune or therapeutic response in the animal. The vector can include and express an exogenous nucleic acid molecule encoding an epitope or gene product of interest. The systemic immune response can be to or from the epitope or gene product. The nucleic acid molecule can encode an epitope of interest and/or an antigen of interest and/or a nucleic acid molecule that stimulates and/or modulates an immunological response and/or stimulates and/or modulates expression, e.g., transcription and/or translation, such as transcription and/or translation of an endogenous and/or exogenous nucleic acid molecule; e.g., one or more of influenza hemagglutinin, influenza nuclear protein, tetanus toxin C-fragment, anthrax protective antigen, HIV gp 120, human carcinoembryonic antigen, and/or a therapeutic, an immunomodulatory gene, such as co-stimulatory gene and/or a cytokine gene. The immune response can be induced by the vector expressing the nucleic acid molecule in the animal's cells. The immune response can be against a pathogen or a neoplasm. A prophylactic vaccine or a therapeutic vaccine or an immunological composition can include the vector.
A method of non-invasively inducing a systemic immune response, comprising topically administering, an adenoviral vector that encodes a gene of interest and expresses a protein encoded by the gene of interest, to the skin of a mammal, in an effective amount to induce said systemic immune response to said protein, wherein a systemic immune response to said protein is induced in said mammal.
A method of non-invasively inducing a systemic immune response comprising topically administering a DNA viral vector complex that encodes a gene of interest and expresses a protein encoded by the gene of interest, to the skin of a mammal, in an effective amount to induce said systemic immune response to said protein, wherein a systemic immune response to said protein is induced in said mammal.
A method of non-invasively inducing a systemic immune response, comprising topically administering, a DNA viral vector that encodes a gene of interest and expresses a protein encoded by the gene of interest, to the skin of a mammal, in an effective amount to induce said systemic immune response to said protein, wherein a systemic immune response to said protein is induced in said mammal.
A method of non-invasively inducing a protective systemic immune response, comprising topically administering, a DNA viral vector that encodes a gene of interest and expresses a protein encoded by the gene of interest, to the skin of a mammal, in an effective amount to induce said protective systemic immune response to said protein, wherein a systemic immune response to said protein is induced in said mammal;
Dependencies are inferred from the claim text.