Back to results
US 6,348,185 B1Granted
Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy
AssigneeWashington University School of Medicine
InventorDavid Piwnica-Worms
Life of this patent
Estimating the term…
Abstract
Methods and compositions for medical imaging, evaluating intracellular processes and components, radiotherapy of intracellular targets, and drug delivery by the use of novel cell membrane-permeant peptide conjugate coordination and covalent complexes having target cell specificity are provided. Kits for conjugating radionuclides and other metals to peptide coordination complexes are also provided.
Claims21
A compound, comprising:
- a cell membrane-permeant peptide;
- a diagnostic or pharmaceutically active substance;
- and
- a functional linker moiety linking said peptide and said diagnostic or pharmaceutically active substance,
- wherein said functional linker moiety confers target cell specificity to said compound,
- or a pharmaceutically acceptable salt of said compound.
3 more elements
A composition, comprising a compound comprising:
- a cell membrane-permeant peptide;
- a diagnostic or pharmaceutically active substance;
- and
- a functional linker moiety linking said peptide and said diagnostic or pharmaceutically active substance,
- wherein said functional linker moiety confers target cell specificity to said compound.
2 more elements
A kit, comprising a compound comprising:
- a cell membrane-permeant peptide;
- a metal chelation ligand;
- and
- a functional linker moiety linking said peptide and said metal chelation ligand,
- wherein said functional linker moiety confers target cell specificity to said compound, and
- a reducing agent capable of reducing a metal that can be coordinately incorporated into said metal chelation ligand.
3 more elements
A method for imaging cells in vivo, comprising:
- administering to an animal a cell imaging effective amount of a compound comprising:
- a cell membrane-permeant peptide;
- a chelated radionuclide or a chelated relaxivity metal;
- and
- a functional linker moiety linking said peptide and said chelated radionuclide or said chelated relaxivity metal, wherein said functional linker confers target cell specificity to said compound, and
- monitoring the location of said radionuclide or relaxivity metal within said animal.
3 more elements
Dependencies are inferred from the claim text.