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US 6,346,614 B1Granted
Hybrid oligonucleotide phosphorothioates
AssigneeHybridon, Inc.
InventorsValeri Metelev, Sudhir Agrawal
Life of this patent
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Abstract
The invention provides hybrid oligonucleotides having phosphorothioate or phosphorodithioate internucleotide linkages, and both deoxyribonucleosides and ribonucleosides or 2′-substituted ribonucleosides. Such hybrid oligonucleotides have superior properties of duplex formation with RNA, nuclease resistance, and RNase H activation.
Claims15
A pharmaceutical formulation comprising an oligonucleotide in a pharmaceutically acceptable carrier, wherein the oligonucleotide comprises a deoxyribonucleotide, a 2′-substituted ribonucleotide, and a phosphorothioate or a phosphorodithioate internucleotide linkage.
Dependencies are inferred from the claim text.