Compositions and methods for inhibiting cox-2 expression and treating cox-2 associated disorders by using cox-2 antisense oligonucleotides

Abstract

The invention features antisense oligonucleotide molecules that specifically bind polynucleotides encoding COX-2. The present invention provides antisense oligonucleotides capable of inhibiting COX-2 expression, and methods of use thereof to reduce activity of COX-2 in tissues in order to treat diseases such as, for example, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, chronic liver disease, ulcerative colitis, cell proliferative disorders, and inflammation associated with Alzheimer's Disease and stroke.

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