# US 6,339,725 B1 · Methods of modulating aspects of brain neural plasticity by vagus nerve stimulation

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- Number: US 6,339,725 B1
- Document ID: US6339725B1
- Status: Granted
- Kind: B1
- Application number: 09/613,368
- Filed: 2000-07-10
- Granted: 2002-01-15
- Earliest claimed: 2000-07-10
- Web page: https://patentgrep.com/patent/US6339725B1

## CPC

- A61N 1/36082: {Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease}
- A61N 1/36053: {adapted for vagal stimulation (A61N1/36114 takes precedence)}
- A61N 1/36064: {Epilepsy}
- A61N 1/36157: {Current (A61N1/3616 takes precedence)}
- A61N 1/36167: {Timing, e.g. stimulation onset}
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)

## Abstract

Methods of modulating brain neural plasticity, improving memory and learning, improving recovery from traumatic brain injury, preventing epilepsy, treating memory disorders and chronic memory impairment, and treating persistent impairment of consciousness in humans and animals by vagus nerve stimulation are provided. These methods comprise selecting an appropriate human or animal subject and applying to the subject's vagus nerve an electrical stimulation signal having parameter values effective in modulating the electrical activity of the vagus nerve in a manner so as to modulate the activity of preselected portions of the brain.