Method of manufacturing phosphine compound

Abstract

A method of preparing a compound (I) of general formula (R3—C)2P—L1—X—L2—P—(C—R3)2, in which R is independently a pendant, optionally substituted, organic group through which the group is linked to tertiary carbon atoms C; L1 and L2 are independently, a linking group selected from an optionally substituted lower alkylene chain connecting the respective phosphorous atom to the group X, and X is a bridging group comprising an optionally substituted aryl moiety to which the phosphorous atoms are linked on available adjacent carbon atoms; comprising: (i) reacting together a compound (II) of formula A—L1—X—L2—A, in which A is a halogen atom, with a metal M in a suitable solvent or form an intermediate compound (III) of formula: A—M—L1—X—L2—M—A; (ii) reacting said intermediate compound (III) with a compound (IV) of formula: (R3—C)2P—A1, wherein A1 is a halogen atom which may be the same as or different from A, to form said compound (I).

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