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US 6,335,366 B2Granted
Naphthyloxy acetic acid derivatives and a pharmaceutical composition comprising them as an active ingredient
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The naphthyloxyacetic acid derivatives of the formula (I) wherein A is H, -(alkylene)COOR1, -(alkylene)CONR2R3, -(alkylene)OH, -(alkylene)tetrazole, -(alkylene)CN; E is single bond or alkylene; G is —S—, —SO—, —SO2—, —O— or —NR4—; L is alkylene, —(CH2)m—CH═CH—(CH2)n— or —(CH2)x—CH(OH)—(CH2)y—; M is phenyl, phenyl(thio, oxy, amino), diphenylmethyl, diphenylmethyl(thio, oxy, amino), and pharmaceutical composition comprising them as an active ingradient. The compounds of the formula (I) can combine PGE2 receptor and exhibit the activity to antagonize or agonize for PGE2 receptor. Therefore, they are useful as anti-hyperlipemia, for the prevention of abortion, for analgesics, as antidiarrheals, sleep inducer, diuretic, anti-diabetes, abortient, cathartics, antiulcer, anti-gastritis or antihypertensive etc.
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Not condensed with other rings: five-membered rings
Having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring: containing hydroxy or O-metal groups
The non-carboxylic part of the ether containing six-membered aromatic rings: the oxygen atom of the ether group being bound to a non-condensed…
The oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring: ethers of hydroxy-acetic acid , e.g. substitutes on…
Term ended 26 Jan 2018 (estimated)
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