US 6,335,343 B1 · Inhibitors of prenyl-protein transferase

Abstract

The present invention comprises piperazine/piperazinone-containing compounds having multicyclic ring system substituents on one of the piperazine/piperazinone nitrogens, which inhibit prenyl-protein transferases, including farnesyl-protein transferase and geranylgeranyl-protein transferase type I. Such therapeutic compounds are useful in the treatment of cancer.

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Facts

Application

09/516,945Filed 1 Mar 2000

Granted

1 Jan 2002

Term ends

Not estimatedThe source records don’t support an estimate.

Classification13 codes

C07D 233/64
Having two double bonds between ring members or between ring members and non-ring members: with substituted hydrocarbon radicals attached to ring…
A61P 1/16
Drugs for disorders of the alimentary tract or the digestive system: for liver or gallbladder disorders, e.g. hepatoprotective agents,…
A61P 9/10
Drugs for disorders of the cardiovascular system: for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary…
A61P 13/12
Drugs for disorders of the urinary system: of the kidneys

Inhibitors of prenyl-protein transferase

Life of this patent

Abstract

Claims0

Inhibitors of prenyl-protein transferase

Life of this patent

Abstract

Claims0