US 6,335,033 B2 · Melt-extrusion multiparticulates

Abstract

A unit dose sustained-release oral dosage form containing a plurality of melt-extruded particles, each consisting essentially of a therapeutically active agent, one or more retardants, and an optional water-insoluble binder is disclosed. The particles have a length of from about 0.1 to about 12 mm and can be of varying diameters and each unit dose provides a release of therapeutically active agents over at least about 8 hours. Methods of preparing the unit doses as well as extrusion processes and methods of treatment are also disclosed.

Claims0

Dependent claims

Claims aren’t available for this document.

Facts

Application

09/358,828Filed 22 Jul 1999

Published

US 2001/0033865 A125 Oct 2001

Granted

1 Jan 2002

Term ends

Not estimatedThe source records don’t support an estimate.

Classification16 codes

A61K 9/1635
Organic macromolecular compounds: obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, polyacrylates
A61K 9/1617
Excipients; Inactive ingredients: organic compounds, e.g. phospholipids, fats
A61K 9/1652
Organic macromolecular compounds: polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
A61K 9/1694
Processes: resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Melt-extrusion multiparticulates

Life of this patent

Abstract

Claims0

Melt-extrusion multiparticulates

Life of this patent

Abstract

Claims0