Processes for the preparation of fluorinated benzoic acids
AssigneeOtsuka Pharmaceutical Co., Ltd.
InventorsAkihiro Hashimoto, Satoshi Matsuda, Kuninori Tai, Hitoshi Tone, Takao Nishi, Jun-ichi Minamikawa, Michiaki Tominaga
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Abstract
An object of the present invention is to provide a commercially advantageous process for preparing a fluoro benzoic acid. The process according to the present invention comprises either alkylating a fluoro benzoic acid of the formula wherein R1 is halogen, or reducing a fluoro benzoic acid of the formula wherein R1 is as defined above and R2 is lower alkyl to thereby produce a fluoro benzoic acid represented by the formula wherein R1 and R2 are as defined above.
Claims18
A process for preparing a fluoro benzoic acid of the formula (2)
- wherein R1 is halogen and R2 is C1-6 alkyl,
- which comprises alkylating a fluoro benzoic acid of the formula (3)
- wherein R1 is as defined above.
A process for preparing a fluoro benzoic acid of the formula (2)
- wherein R1 is halogen and R2 is C1-6 alkyl,
- which comprises reducing a fluoro benzoic acid of the formula (4)
- wherein R1 and R2 are as defined above.
Dependencies are inferred from the claim text.