Process for preparing tert-alkyl ester from carboxylic acid
AssigneeSumika Fine Chemicals Co., Ltd.
InventorsTetsuya Shintaku, Kiyoshi Sugi, Tadashi Katsura, Nobushige Itaya
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Abstract
A process for preparing a tert-alkyl carboxylic acid ester represented by the formula (III): wherein R1 is an organic group; and each of R2 and R3 is independently an alkyl group having 1 to 4 carbon atoms, comprising reacting a carboxylic acid represented by the formula (I): R1—COOH (I) wherein R1 is as defined above, with a vinylidene compound represented by the formula (II): wherein R2 and R3 are as defined above, in the presence of a phosphorus halide. The tert-alkyl carboxylic acid ester can be used as intermediates for pharmaceuticals such as antibiotics.
Claims4
A process for preparing a tert-alkyl carboxylic acid ester represented by the formula (III):
- wherein R1 is an organic group;
- and each of R2 and R3 is independently an alkyl group having 1 to 4 carbon atoms, comprising reacting a carboxylic acid represented by the formula (I):
- R1—COOH (I)
- wherein R1 is as defined above,
- with a vinylidene compound represented by the formula (II):
- wherein R2 and R3 are as defined above,
- in the presence of a phosphorus halide.
Dependencies are inferred from the claim text.