Therapeutic derivatives of diphosphonates
AssigneeEliza Nor Biopharmaceuticals, Inc.
InventorsPal Herczegh, John F. Hartmann, Arpad Kovacs, Ferenc J. Sztaricskai, Miklos Hornyak
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Abstract
Compounds having utility in achieving the foregoing objects of the invention are prepared by reacting a 2,2-bis-(disubstituted-phosphoryl)-ethylsulfanyl-acetic acid compound with a pharmaceutically active chemical entity effective to treat the underlying disease state or with non-pharmaceutical entities such as pesticides, insecticides, fungicides or poisons for vermin.
Claims13
A compound of the formula
- wherein R is H or an aliphatic group of from 1 to 10 carbon atoms and A is an organic group.
A compound of the formula A—X—Z wherein A is the residue of a pharmaceutically active compound, X is a linking group that is cleavable in vivo or in vitro by esterase and Z is
- wherein R is H or alkyl of from 1 to 10 carbons.
Dependencies are inferred from the claim text.