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US 6,333,408 B1Granted
Oligonucleotides inhibitors of PAI-1 MRNA
AssigneeKureha Chemical Industry Co., Ltd.
InventorsMasaru Motojima, Takao Ando
Life of this patent
Estimating the term…
Abstract
An oligonucleotide containing a sequence of SEQ ID NO: 1: CAGTGAGTGG GTGGGGCTGG AACA, or SEQ ID NO: 2: TTAAGCTTTT ACCATGGTAA CCCC; a pharmaceutical composition comprising the oligonucleotide; and a method for treating or preventing a disease accompanied by an extracellular matrix deposition, are disclosed.
Claims5
An isolated double-stranded oligonucleotide consisting of a plus strand of a sequence of SEQ ID NO:
- 1 or SEQ ID NO:
- 2 and a minus strand of a sequence complementary to said sequence of SEQ ID NO:
- 1 or SEQ ID NO:
- 2.
1 more element
An isolated hairpin oligonucleotide comprising a plus strand region having a sequence of SEQ ID NO:
- 1 or SEQ ID NO:
- 2, an oligonucleotide region capable of forming a loop region, and a minus strand region having a sequence complementary to said sequence of SEQ ID NO:
- 1 or SEQ ID NO:
- 2 so that said plus strand region, said loop region and said minus strand region are linearly arranged in this sequential order, and a stem region is formed by said plus strand region and said minus strand region.
1 more element
An isolated dumbbell oligonucleotide comprising a plus strand region having a sequence of SEQ ID NO:
- 1 or SEQ ID NO:
- 2, an oligonucleotide region capable of forming a first loop region, a minus strand region having a sequence complementary to said sequence of SEQ ID NO:
- 1 or SEQ ID NO:
- 2, and an oligonucleotide region capable of forming a second loop region so that said plus strand region, said first loop region, said minus strand region, and said second loop region are cyclically arranged in this sequential order, and a stem region is formed from said plus strand region and said minus strand region.
1 more element
Dependencies are inferred from the claim text.