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US 6,333,405 B1Granted
High affinity humanized anti-CEA monoclonal antibodies
AssigneeThe Dow Chemical Company
InventorsW. H. Kerr Anderson, Philip R. Tempest, Frank J. Carr, William J. Harris, Kathryn Armour
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Abstract
Novel humanized monoclonal antibodies, fragments or derivatives thereof which specifically bind carcinoembryonic antigen (CEA) are provided as well as methods for their manufacture. These humanized antibodies are useful in the treatment of cancers which express CEA as well as for diagnostic purposes, e.g., for in vivo imaging of tumors or cancer cells which express CEA.
Claims5
Nucleic acid from which can be expressed either:
- A) a humanized antibody which specifically binds carcinoembryonic antigen (“CEA”) wherein said humanized antibody comprises:
- 1) at least one humanized VH having the amino acid sequence of any one of SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, and SEQ ID NO:12;
- and
- 2) at least one humanized VL having the amino acid sequence of any one of SEQ ID NO:15, SEQ ID NO:16, and SEQ ID NO:
- 17;
- or
- B) a humanized antibody fragment thereof which specifically binds CEA.
4 more elements
Dependencies are inferred from the claim text.