Pharmaceutical composition containing zafirlukast
AssigneeZeneca Limited
InventorsSusan Jane Corvari, Karen Beth Main, Bharvnish Vinod Parikh
Life of this patent
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Abstract
Pharmaceutical compositions of 4-(5-cyclopentyloxycarbonylamino-1-methylindol-3-ylmethyl)-3-methoxy-N-o-tolylsulfonylbenzamide and a gelling agent, in particular hydroxypropylmethylcellulose, are described for treating asthma and related diseases. Processes for the preparation of the compositions are described.
Claims8
A pharmaceutical composition comprising
- 4-(5-cyclopentyloxycarbonylamino-1-methylindol-3-ylmethyl)-3-methoxy-N-o-tolylsulfonylbenzamide or a pharmaceutically acceptable salt thereof, and, as gelling agent, hydroxypropylmethylcellulose, wherein the hydroxypropylmethylcellulose is selected from the group consisting of:
- a) a hydroxypropylmethylcellulose having a viscosity of about 40 to 60 cps, a methoxy content of about 20 to 30% by weight and a hydroxypropoxy content of from about 7 to less than 9% by weight;
- b) a hydroxypropylmethylcellulose having a viscosity of about 3,500 to 5,600 cps, a methoxy content of about 28 to 30% by weight and a hydroxypropoxy content of about 7 to 12% by weight;
- c) a hydroxypropylmethlylcellulose having a viscosity of about 80 to 120 cps, a methoxy content of about 19 to 24% by weight and a hydroxypropoxy content of from about 7 to less than 9% by weight;
- and
- d) a hydroxypropylmethylcellulose having a viscosity of about 5,500 to 5,600 cps, a methoxy content of about 19 to 24% by weight and a hydroxypropoxy content of about 7 to 12% by weight, or mixtures thereof.
A process for preparing a pharmaceutical composition comprising 4-(5-cyclopentyloxycarbonylamino-1-methylindol-3-ylmethyl)-3-methoxy-N-o-tolylsulfonylbenzamide or a pharmaceutically acceptable salt thereof, and, as gelling agent, hydroxypropylmethylcellulose, wherein the hydroxypropylmethylcellulose is selected from the group consisting of:
- a) a hydroxypropylmethylcellulose having a viscosity of about 50 to 60 cps, a methoxy content of about 20 to 30% by weight and a hydroxypropoxy content of from about 7 to less than 9% by weight;
- b) a hydroxypropylmethylcellulose having a viscosity of about 3,500 to 5,600 cps, a methoxy content of about 28 to 30% by weight and a hydroxypropoxy content of about 7 to 12% by weight;
- c) a hydroxypropylmethylcellulose having a viscosity of about 80 to 120 cps, a methoxy content of about 19 to 24% by weight and a hydroxypropoxy content of from about 7 to less than 9% by weights;
- and
- d) a hydroxypropylmethylcellulose having a viscosity of about 3,500 to 5,600 cps, a methoxy content of about 19 to 24% by weight and a hydroxypropoxy content of about 7 to 12% by weight, or mixtures thereof.
Dependencies are inferred from the claim text.