Use of nitric oxide donors and/or substrates or nitric oxide inhibitors for regulating cervical dilatation and extensibility
AssigneesSchering Corporation, The University of Texas System
InventorsKristof Chwalisz, Robert E. Garfield
Life of this patent
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Abstract
The invention describes the regulation of cervical dilatation and extensibility by the use of nitric oxide donors and/or substrates or nitric oxide inhibitors. There can be used either (a) at least one nitric oxide donor and/or substrate for manufacture of a medicament to be administered locally intracervically or intravaginally for induction of cervical ripening or (b) at least one nitric oxide inhibitor for manufacture of a medicament to be administered locally intracervically or intravaginally for treatment of cercvical insufficiency or preterm labor.
Claims31
A method of inducing cervical dilatation and/or extensibility, comprising administering, intracervically, intravaginally, or to the surface of the cervix, to a patient in need of such treatment an amount of at least one nitric oxide donor and/or substrate effective to induce cervical ripening.
A method of inhibiting cervical dilation and/or extensibility, comprising administering, intracervically, intravaginally, or to the surface of the cervix, to a patient in need of such treatment, an amount of at least one nitric oxide inhibitor effective to inhibit said dilation and/or extensibility.
A method of inducing labor, comprising administering, intracervically, intravaginally, or to the surface of the cervix, to a patient in need of such treatment, an amount of at least one nitric oxide donor and/or substrate effective to promote labor.
A method of promoting labor, comprising administering, intracervically, intravaginally, or to the surface of the cervix, to a patient in need of such treatment, an amount of at least one nitric oxide donor and/or substrate effective to induce labor.
A method of inhibiting preterm labor, comprising administering, intracervically, intravaginally, or to the surface of the cervix, to a patient in need of such treatment, an amount of at least one nitric oxide inhibitor effective to inhibit preterm labor.
A method of inducing abortion, comprising administering, intracervically, intravaginally, or to the surface of the cervix, to a patient in need of such treatment, an amount of at least one nitric oxide donor and/or substrate effective to induce abortion.
A method of treating cervical insufficiency, comprising administering, intracervically, intravaginally, or to the surface of the cervix, to a patient in need of such treatment, an amount of at least one nitric oxide inhibitor effective to treat cervical insufficiency.
Dependencies are inferred from the claim text.