Sulfonamide-substituted fused 7-membered ring compounds, their use as a medicament, and pharmaceutical preparations comprising them

A compound according to formula I,

• in which:
• X1 is —O—;
• X2 is —CR(1)R(2)—,
• R(1) and R(2)
• each independently represent hydrogen or alkyl having 1, 2 or 3 carbon atoms;
• X3 is —CH2 or —C(CH3)2—;
• X4 is —CH2—;
• Y1 is CH;
• Y2 is CH;
• Y4 is CH;
• Y3 is —CR(12)—;
• R(12)
• is F, Cl, Br, alkyl having 1, 2 or 3 carbon atoms, CN, CF3, NO2, —Z—CmH2m—R(13);
• Z is —O—, —CO—, —CO—O—, —O—CO—, —S—, —SO—, —SO2—, —SO2NR(14)— or —CONR(14)—;
• R(14) is hydrogen or alkyl having 1, 2 or 3 carbon atoms;
• m is 1,2 or 3;
• R(13) is hydrogen, CF3, pyridyl or phenyl;
• R(3) is R(17)—CxH2x—,
• R(17) is methyl;
• x is zero, 1 or 2;
• R(4) is —CrH2r—R(20),
• where a CH2 group of the group CrH2r can be replaced by —O—, —CO—O—, —O—CO— or —CONR(21)—;
• R(21) is hydrogen or alkyl having 1, 2 or 3 carbon atoms;
• r is zero, 1, 2, 3, 4, 5 or 6;
• R(20) is methyl or CF3;
• R(5) is hydrogen;
• in all its stereoisomeric forms and mixtures thereof in any desired ratios, or a physiologically tolerable salt thereof.