3-Benzylpiperidine
AssigneeMerck Patent Gellschaft mit Beschrankter
InventorsHenning Boettcher, Helmut Pruecher, Hartmut Greiner, Christoph Seyfried, Andrew Barber, Joseph Maria Martinez
Life of this patent
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Abstract
The invention relates to piperidine derivatives of the formula I in which R1, R2, m and k have the meanings indicated in claim 1, and their salts, novel intermediates and processes for the preparation of the compounds according to the invention. The compounds of the formula I are potent a receptor ligands and show 5-HT reuptake-inhibiting actions and can be used for the production of medicaments, for example for the treatment of disorders of the central nervous system, of strokes, brain or bone marrow traumata or of ischaemic states.
Claims14
A compound of the formula I
- in which
- R1 is 2- or 3-indolyl which is unsubstituted or mono- or disubstituted by Hal, CN, A, AO, OH, CONH2, CONHA, CONA2, COOH and/or COOA, or is 5H-1,3-dioxolo-[4,5-f]-7-indolyl,
- R2 is benzyl which is unsubstituted or mono-, di- or trisubstituted on the phenyl ring by A, AO, OH, Hal, CN, NO2, NH2, NHA, NA2, CF3, COA, CONH2, COOH, CONHA, CONA2, OSO2A and/or OSO2CF3 or is phenylhydroxymethyl,
- Hal is F, Cl, Br or I,
- A is straight-chain or branched alkyl having 1-10 C atoms, which can be substituted by 1 to 5 F and/or Cl atoms or is cycloalkyl having 3-10 C atoms,
- k is 0 or 1 and
- m is 1, 2, 3 or 4
- and their salts and solvates.
Dependencies are inferred from the claim text.