Stabilized pharmaceutical compositions containing bupropion hydrochloride

A pharmaceutical composition comprising bupropion hydrochloride and a pharmaceutically acceptable stabilizer in an effective stabilizing amount, in which at least about 80% of an initial potency of said bupropion hydrochloride in the composition is maintained after storage for one week at 60° C. and 75% relative humidity, and, wherein said stabilizer is selected from the group consisting of a salt of an organic base and a salt of an inorganic acid.

A method of stabilizing bupropion hydrochloride in a pharmaceutical composition so that at least about 80% of the potency of bupropion hydrochloride is maintained after storage for one week at 60° C. and 75% relative humidity, wherein said method comprises the step of mixing bupropion hydrochloride with a pharmaceutically acceptable stabilizer in an effective stabilizing amount.

A method of stabilizing bupropion hydrochloride in a pharmaceutical composition so that at least about 80% of the potency of the bupropion hydrochloride is maintained after storage for one week at 60° C. and 75% relative humidity, wherein said method comprises the step of mixing bupropion hydrochloride with a pharmaceutically acceptable stabilizer in an effective stabilizing amount and, where the step of mixing utilizes a dry blend of said bupropion hydrochloride, said pharmaceutically acceptable stabilizer, and other pharmaceutically acceptable excipients.

A pharmaceutical composition comprising bupropion hydrochloride and a pharmaceutically acceptable stabilizer in an effective stabilizing amount, in which at least 80% of an initial potency of said bupropion hydrochloride in the composition is maintained after storage for 4 or 12 weeks at 60° C. and 75% relative humidity.

A pharmaceutical composition comprising bupropion hydrochloride and a pharmaceutically acceptable stabilizer in an effective stabiling amount, in which at least about 80% of an initial potency of said bupropion hydrochloride in the composition is maintained after storage for 4 or 12 weeks at 40° C. and 75% relative humidity, and, wherein said stabilizer is a salt of an organic base or a salt of an inorganic acid.

A method of stabilizing bupropion hydrochloride in a pharmaceutical composition so that at least 80% of the potency of bupropion hydrochloride is maintained after storage for 4 or 12 weeks at 60° C. and 75% relative humidity, wherein said method comprises the step of mixing a dry blend of bupropion hydrochloride with a pharmaceutically acceptable stabilizer in an effective stabilizing amount.

A method of stabilizing bupropion hydrochloride in a pharmaceutical composition so that at least 80% of the potency of the bupropion hydrochloride is maintained after storage for 4 or 12 weeks at 40° C. and 75% relative humidity, wherein said method comprises the step of mixing a dry blend of bupropion hydrochloride with a pharmaceutically acceptable stabilizer in an effective stabilizing amount, and, wherein said stabilizer is a salt of an organic base or a salt of an inorganic acid.

A pharmaceutical composition comprising bupropion hydrochloride and a pharmaceutically acceptable stabilizer in an effective stabilizing amount, in which the stabilizer is selected from the group consisting of an organic base and a salt of an inorganic acid.

A pharmaceutical composition comprising bupropion hydrochloride and a pharmaceutically acceptable stabilizer in an effective stabilizing amount, in which the stabilizer is selected from the group consisting of an organic base and a salt of an inorganic acid, and in which at least about 80% of an initial potency of said bupropion hydrochloride in the composition is maintained after storage for one week at 60° C. and 75% relative humidity.