4′-C-ethynyl purine nucleoside compounds
AssigneeYamasa Corporation
InventorsHiroshi Ohrui, Eiichi Kodama, Satoru Kohgo, Hiroaki Mitsuya, Masao Matsuoka, Kenji Kitano
Life of this patent
Estimating the term…
Abstract
The invention provides 4′-C-ethynyl purine nucleosides represented by formula [I]: wherein B represents a base selected from the group consisting of purine and derivatives thereof; X represents a hydrogen atom or a hydroxyl group; and R represents a hydrogen atom or a phosphate residue; and a pharmaceutical composition containing any one of the compounds and a pharmaceutically acceptable carrier. Preferably, the composition is used as an anti-HIV agent or a drug for treating AIDS.
Claims12
A 4′-C-ethynyl purine nucleoside represented by the following formula (1):
- wherein B represents a purin-9-yl or a derivative thereof, wherein the derivative is purin-9-yl having a substituent selected from the group consisting of a halogen atom, an alkyl group, a haloalkyl group, an alkenyl group, a haloalkenyl group, an alkynyl group, an amino group, an alkylamino group, a hydroxyl group, a hydroxyamino group, an aminoxy group, an alkoxy group, a mercapto group, an alkylmercapto group, an aryl group, an aryloxy group, and a cyano group;
- X represents a hydrogen atom or a hydroxyl group;
- and R represents a hydrogen atom or a phosphate residue.
Dependencies are inferred from the claim text.