Useful properties of human lactoferrin and variants thereof
AssigneePharming B.V.
InventorsJan Nuijens, Patrick van Berkel
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Abstract
The invention provides compositions containing human lactoferrin, or lactoferrin variants deleted for one or more arginine residues in the amino-terminal region of the protein (i.e., in the first basic cluster), and methods of using the compositions. The human lactoferrin, or lactoferrin variants are useful for treatment of human diseases and conditions, including inflamation.
Claims20
A pharmaceutical composition comprising a human lactoferrin variant and a carrier, wherein the composition is substantially free of other human proteins, wherein the lactoferrin variant binds heparin with lower affinity than does natural lactoferrin, and wherein the human lactoferrin variant differs from human lactoferrin by a deletion or substitution of at least one arginine residue in the first basic cluster with an acidic or neutral amino acid residue.
A pharmaceutical composition comprising a human lactoferrin variant and a carrier, wherein the composition is substantially free of other human proteins, wherein the lactoferrin variant binds heparin with lower affinity than does natural lactoferrin, and wherein the human lactoferrin variant is hLF-2N, hLF-3N, hLF-4N, or hLF-5N.
Dependencies are inferred from the claim text.