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AssigneeTakara Shuzo Co., Ltd.
InventorsKazutoh Takesako, Naoyuki Awazu, Mitsuhiro Ueno, Yoshimi Onishi, Ikunoshin Kato
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The antibiotic TKR2999 having the physicochemical properties described below and its pharmacologically acceptable salt: (1) FAB-MS m/z 971 [M+H)]+, (2) the molecular formula: C44H78N10O14, and high-resolution FAB-MS m/z 971.5776 [M+H]+, (3) the ultraviolet absorption spectrum in methanol has an end absorption, (4) the infrared absorption spectrum by KBr method shows the major absorption wave numbers at 3320, 2920, 1680, 1540, 1210, 1140, 840, 800, and 720 cm−1, (5) aspartic acid, threonine, serine, glycine, alanine, β-alanine, and ornithine are detected by the amino acid analysis using ninhydrin reaction, and (6) the solubility is that it is soluble in methanol, and practically insoluble in hexane, chloroform, and water.
The antibiotic TKR2999 having the physicochemical properties of (1), (2), (3), (4), and (5) described below and its pharmacologically acceptable salt:
A method for producing the antibiotic TKR2999, which comprises cultivating a strain of microorganism belonging to the class Fungi Imperfecti and capable of producing TKR2999 and harvesting the objective antibiotic from the resulting culture broth.
A biologically pure culture of a microorganism belonging to the class Fungi Imperfecti which produces the antibiotic TKR2999.
Dependencies are inferred from the claim text.