Nucleic acids sequence, stress-induced proteins and uses thereof
AssigneeUniversity of Medicine and Dentistry of New Jersey
InventorsMasayori Inouye, Pamela Jones, Jean-Pierre Etchegaray, Weining Jiang, N. Stephen Pollitt, Joel Goldstein
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Abstract
A family of stimuli-induced in particular stress or cold-shock induced genes and proteins are disclosed which have conserved amino acid domains. Nucleic acid sequences of the genes and the promoters are also described. Various utilities of the promoters and of the proteins are disclosed.
Claims11
An isolated DNA molecule comprising a prokaryotic promoter wherein said promoter is induced under conditions that elicit a cold shock response, wherein said conditions comprise a decrease in temperature below the normal physiological growth temperature of the bacterium.
An isolated DNA molecule comprising a prokaryotic promoter induced under conditions that elicit the cold shock response, wherein the promoter comprises nucleotides 1-534 of CspA (SEQ ID NO:
- 19).
An isolated DNA molecule comprising a prokaryotic promoter, wherein said promoter is induced under conditions that elicit a cold shock response, said promoter comprising the nucleic acid sequences TTGCTT-17 base pairs-GTTAAT.
A vector comprising an isolated DNA molecule comprising a prokaryotic promoter, wherein said promoter is induced under conditions that elicit a cold shock response, said promoter comprising the nucleic acid sequence TTGCTT-17 base pairs-GTTAAT.
An isolated DNA cold-shock promoter which comprises the TTGCTT-17 base pairs-GTTAAT sequences.
An isolated DNA molecule comprising a promoter derived from a prokaryotic cell, wherein said promoter is repressed under conditions that elicit a cold shock response, wherein said conditions comprise a decrease in temperature below the normal physiological growth temperature of said prokaryotic cell.
Dependencies are inferred from the claim text.