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US 6,333,189 B1Granted
Method of making an electrotransport device
AssigneeAlza Corporation
InventorsLeslie A. Holladay, Kevin R. Oldenburg
Life of this patent
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Abstract
Method of making an electrotransport device containing an analog of a parent polypeptide having one or more amino acid residues substituted relative to the parent polypeptide with an amino acid residue selected from the group consisting of proline, glycine and asparagine.
Claims5
A method of making an electrotransport device for delivering a polypeptide agent through a body surface by electrotransport, said method comprising:
- (a) providing a first electrode;
- (b) providing a second electrode;
- (c) providing a power source electrically connected to said first and said second electrodes;
- (d) providing at least one donor reservoir associated with an electrode;
- and
- (e) providing a therapeutically effective amount of the polypeptide agent wherein the polypeptide agent is an analog of a parent polypeptide wherein said parent polypeptide comprises an α-helix and/or a β-sheet segment, the analog polypeptide having one or more amino acid residues substituted relative to said parent polypeptide with an amino acid residue selected from the group consisting of Pro, Gly and Asn to disrupt said α-helical and/or β-sheet segment;
- and
- (f) adding said polypeptide agent to said donor reservoir to result in an electrotransport device for delivering said polypeptide agent through said body surface.
5 more elements
Dependencies are inferred from the claim text.