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US 6,333,186 B1Granted
Modified forms of Hepatitis C NS3 protease for facilitating inhibitor screening and structural studies of protease: inhibitor complexes
AssigneeBristol-Myers Squibb Company
InventorsMichael Wittekind, Steven Weinheimer, Yaqun Zhang, Valentina Goldfarb
Life of this patent
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Abstract
The present invention relates to modified Hepatitis C NS3 proteases and modified Hepatitis C NS4a-NS3 fusion proteases. These proteins are highly soluble and are useful for NMR spectroscopy, X-ray crystallography, and inhibitor screening. DNA constructs are also provided.
Claims26
A modified HCV NS3 protease comprising at least one substitution in HCV NS3 protease of a hydrophobic α-helix 0 amino acid residue to a hydrophilic amino acid residue wherein said modified HCV NS3 protease exhibits protease activity.
Dependencies are inferred from the claim text.