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AssigneeThe Trustees of Columbia University in the City of New York
InventorsThomas M. Jessell, Konrad Basler, Toshia Yamada
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This invention provides an isolated vertebrate nucleic acid molecule which encodes dorsalin-1. This invention also provides a nucleic acid probe capable of specifically hybridizing with a sequence included within the sequence of a nucleic acid molecule encoding a dorsalin-1. The invention also provides a vector and host vector system for the production of a polypeptide having the biological activity of dorsalin-1 which comprises the above-described vector in a suitable host. This invention also provides a purified vertebrate dorsalin-1. This invention provides a method for stimulating neural crest cell differentiation, a method for regenerating nerve cells, a method for promoting bone growth, a method for promoting wound healing and a method for treating neural tumor using purified dorsalin-1. This invention further provides a pharmaceutical composition comprising purified dorsalin-1 and a pharmaceutically acceptable carrier. Finally, this invention provides an antibody capable of binding to dorsalin-1.
An isolated nucleic acid comprising the nucleic acid sequence set forth in SEQ ID NO:
The nucleic acid of claim which is RNA.
An isolated nucleic acid which encodes a dorsalin-1 polypeptide, wherein the polypeptide comprises the sequence set forth in SEQ ID NO:
An isolated nucleic acid which encodes a mouse dorsalin-1 polypeptide, wherein the polypeptide comprises the sequence set forth in SEQ ID NO:
Dependencies are inferred from the claim text.