Functionalized nanocrystals as visual tissue-specific imaging agents, and methods for fluorescence imaging
AssigneeBio-Pixels Ltd.
InventorEmilio Barbera-Guillem
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Abstract
Provided is a method of fluorescence imaging of living tissue using functionalized nanocrystals. The method comprises contacting an effective amount of functionalized nanocrystals with the living tissue; exposing the tissue to a spectrum of light suitable for exciting functionalized nanocrystals, present in fluorescently labeled tissue, to emit a emission spectrum comprising a fluorescence peak; and detecting any fluorescence peak emitted by the tissue exposed to the excitation spectrum of light, and obtaining a fluorescence image of the tissue. Also provided is a composition comprising a functionalized nanocrystal which is bound to a substrate in a living tissue.
Claims10
A functionalized nanocrystal bound to a substrate in a living tissue, wherein the functionalized nanocrystal comprises:
- a quantum dot having a core and a shell;
- a layer comprising capping compound operably linked to the quantum dot, wherein capping compound comprises a compound having the formula HS(CH2)nX, wherein X is a carboxylate;
- a layer comprising a diaminocarboxylic acid which is operably linked to capping compound;
- and affinity ligand which is operably linked to diaminocarboxylic acid.
Dependencies are inferred from the claim text.