Nontoxic vernix compositions and method of producing
AssigneeChildren's Hospital Medical Center
InventorsSteven B. Hoath, William L. Pickens, Martha O. Visscher
Life of this patent
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Abstract
A composition containing vernix to provide therapeutic treatment in a human, and a method for using the composition, are disclosed. The composition may contain a natural or synthetic medicament, or may be manipulated to regulate transport properties. The medicament may be, for example, a protectant against ultraviolet radiation or an antioxidant. Various compositions and uses of vernix, both natural and synthetic, are disclosed. The compositions may be used in embodiments such as skin protection, wound healing, and restoration of epidermal barrier function.
Claims53
A composition comprising vernix and a medicament wherein vernix is selected from the group consisting of natural vernix and synthetic vernix, said natural vernix comprising about a 10% lipid fraction by weight, about a 10% protein fraction by weight, and about an 80% volatile fraction by weight, and said synthetic vernix comprising from about a 5% to about a 15% lipid fraction by weight, and from about a 5% to about a 15% protein fraction by weight.
A method for protecting skin from exposure to ultraviolet (UV) radiation comprising applying an effective amount of a composition comprising vermix and a UV protectant in a pharmaceutically acceptable carrier to the skin wherein vernix is selected from the group consisting of natural vernix and synthetic vernix, said natural vernix comprising about a 10% lipid fraction by weight, about a 10% protein fraction by weight, and about an 80% volatile fraction by weight, and said synthetic vernix comprising from about a 5% to about a 15% lipid fraction by weight, and from about a 5% to about a 15% protein fraction by weight.
A method for altering skin coloration comprising applying an effective amount of a composition comprising vernix and a skin colorant in a pharmaceutically acceptable carrier to the skin wherein vernix is selected from the group consisting of natural vernix and synthetic vernix, said natural vernix comprising about a 10% lipid fraction by weight, about a 10% protein fraction by weight, and about an 80% volatile fraction by weight, and said synthetic vernix comprising from about a 5% to about a 15% lipid fraction by weight, and from about a 5% to about a 15% protein fraction by weight.
A method for protecting an epithelial surface from an oxidant comprising applying an effective amount of a composition comprising vernix and an antioxidant in a pharmaceutically acceptable carrier to the surface wherein vernix is selected from the group consisting of natural vernix and syntheticvernix, said natural vernix comprising about a 10% lipid fraction by weight, about a 10% protein fraction by weight, and about an 80% volatile fraction by weight, and said synthetic vernix comprising from about a 5% to about a 15% lipid fraction by weight, and from about a 5% to about a 15% protein fraction by weight.
A method for providing a nutrient comprising providing an effective amount of a composition comprising vernix and the nutrient in a pharmaceutically acceptable carrier.
A synthetic vernix composition having a lipid fraction in the range of about 5-15% by weight and a protein fraction in the range of about 5-15%by weight and further comprising a medicament.
A method of providing a spreadable composition comprising vernix and an effective amount of a surfactant associated protein in a pharmaceutically acceptable carrier to a surface.
A composition comprising vernix and surfactant associated protein B (SP-B) in an amount to spreadably apply said composition to a surface.
A method of treating an epithelial surface by applying a composition comprising an effective amount of vernix and a protein of pulmonary origin in a pharmaceutically acceptable carrier to the surface.
A method to regulate transport in a biological surface comprising applying a vernix composition containing corneocytes to said surface for orientating the corneocytes in the composition.
An antioxidant composition comprising vernix in a pharmaceutically acceptable carrier wherein vernix is selected from the group consisting of natural vernix and synthetic vernix, said natural vernix comprising about a 10% lipid fraction by weight, about a 10% protein fraction by weight, and about an 80% volatile fraction by weight, and said synthetic vernix comprising from about a 5% to about a 15% lipid fraction by weight, and from about a 5% to about a 15% protein fraction by weight.
Dependencies are inferred from the claim text.