Prophylaxis of allergic disease
AssigneeTVW Telethon Institute for Child Health Research Princess Margaret Hospital for Children
InventorPatrick G. Holt
Life of this patent
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Abstract
The invention provides a method for preventing allergic disease in an individual susceptible to such disease, comprising administering an allergen to which the individual has not been sensitized previously. The allergen is administered in a dose and form effective to establish a stable population of allergen-specific T-helper-1-like memory lymphocytes capable of inhibiting activity or amplification of allergen-specific T-helper-2-like lymphocytes responsible for stimulating production of IgE antibodies specific for the allergen. Compositions for use in the method of the invention are also disclosed.
Claims12
A method for the prophylactic treatment of allergic disease triggered by an environmental allergen in a human individual susceptible to such disease, comprising the step of administering to an individual who has not been sensitized by said environmental allergen a dose and form of said environmental allergen effective to induce establishment of a stable population of allergen-specific T-helper-1-like memory lymphocytes, said lymphocytes being capable of inhibiting activity or amplification of allergen-specific T-helper-2-like lymphocytes responsible for stimulating production of IgE antibodies specific for said environmental allergen.
Dependencies are inferred from the claim text.