Methods for treating pain with a modified neurotoxin
AssigneeAllergan Sales, Inc.
InventorsKei Roger Aoki, Minglei Cui
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Abstract
Methods for treating pain by intrathecal administration to a human patient of a therapeutically effective amount of a neurotoxin such as botulinum toxin type A are disclosed.
Claims36
A method for treating pain, the method comprising the step of intraspinal administration of an effective amount of a neurotoxin to a mammal, thereby alleviating pain experienced by the mammal, wherein the neurotoxin is not attached to a neuronal targeting moiety and wherein the neurotoxin is a recombinantly produced botulinum toxin.
A method for the in vivo attenuation of a nociceptive activity or experience of a human patient, the method comprising the step of intraspinal administration to a human patient a therapeutically effective amount of a botulinum toxin, wherin the botolinum toxin is not attached to a neuronal targeting moiety thereby causing an in vivo attenuation of a nociceptive activity or experience of the human patient, wherein the botulinum toxin is a recombinantly produced botulinum toxin.
A method for treating pain, the method comprising the steps of:
- (a) selecting a neurotoxin free of any neuronal targeting moiety;
- (b) choosing a portion of an intraspinal region of a patient which influences pain;
- (c) intraspinally administering an effective amount of the neurotoxin selected, thereby alleviating pain experienced by the patient, wherein the neurotoxin is a recombinant produced botulinum toxin.
A method for treating pain, the method comprising the step of administering an effective amount of a pharmaceutical preparation to an intraspinal region or to a dorsal root ganglion of a mammal, thereby alleviating pain experienced by the mammal, wherein the pharmaceutical preparation comprises a neurotoxin which is free of any neuronal targeting moiety and wherein the neurotoxin is a recombinantly produced botulinum toxin.
Dependencies are inferred from the claim text.