Vaccine composition containing polyribosylribitol phosphate and method for making same
AssigneePasteur Merieux Serums et Vaccins
InventorsFrancois Arminjon, Jean-René Cartier
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Abstract
Vaccine compositions are disclosed which comprise at least one antigen formed by the capsular polysaccharide of Haemophilus influenzae type b or high molecular weight polyribosylribitol phosphate coupled to tetanus anatoxin.
Claims11
A storage-stable, liquid vaccine composition comprising capsular polysaccharide of Haemophilus influenzae type b or polyribosylribitol phosphate having more than 100 monomer repeating units coupled to tetanus anatoxin as well as an aluminium-based adjuvant, wherein the aluminium-based adjuvant has a point of zero charge of less than approximately 7.2.
A process for preparing a storage-stable, liquid vaccine composition comprising capsular polysaccharide of Haemophilus influenzae type b or polyribosylribitol phosphate having more than 100 monomer repeating units coupled to tetanus anatoxin, said process comprising obtaining a vaccine composition and adding an adjuvant to the vaccine composition by means of a suspension of aluminium complexes having a point of zero charge of less than approximately 7.2.
Dependencies are inferred from the claim text.