Process for removing toxins from bodily fluids using zirconium or titanium microporous compositions
AssigneeUop LLC
InventorsJohn D. Sherman, David S. Bem, Gregory J. Lewis
Life of this patent
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Abstract
A process for removing toxins from fluids, such as bodily fluids or a dialysate solution, is disclosed. The process involves contacting the fluid with a microporous ion exchanger to remove toxins in the fluid. The microporous ion exchangers are represented by the following empirical formulae: ApMxZr1−xSinGeyOm (I) and ApMxTi1−xSinGeyOm (II)
Claims24
A process for removing toxins from a fluid selected from the group consisting of a bodily fluid and a dialysate solution, the process comprising contacting the fluid containing the toxins with a microporous ion exchanger at ion exchange conditions thereby removing the toxins from the fluid, the microporous ion exchanger selected from the group consisting of zirconium metallate, titanium metallate and mixtures thereof, the metallates respectively having an empirical formula on an anhydrous basis of:
- ApMxZr1−xSinGeyOm (I)
- and
- ApMxTi1−xSinGeyOm (II)
- where A is an exchangeable cation selected from the group consisting of potassium ion, sodium ion, calcium ion, magnesium ion and mixtures thereof, M is at least one framework metal selected from the group consisting of hafnium (4+), tin (4+), niobium (5+), titanium (4+), cerium (4+), germanium (4+), praseodymium (4+), and terbium (4+), except that M is not titanium in formula (II), “p” has a value from about 1 to about 20, “x” has a value from zero to less than 1, “n” has a value from about 0 to about 12, “y” has a value from 0 to about 12, “m” has a value from about 3 to about 36 and 1≦n+y≦12.
A process for removing toxins from a mammalian body comprising:
- a) filling the peritoneal cavity with a sufficient volume of a first dialysate solution such that the solution contacts the peritoneum for a sufficient time to remove toxins from the blood;
- b) discharging the first dialysate solution from the peritoneal cavity and contacting the first dialysate solution with a microporous ion exchanger at ion exchange conditions, thereby adsorbing the toxins onto the ion exchanger;
- and
- c) collecting a purified dialysate solution;
- the microporous ion exchanger selected from the group consisting of zirconium metallate, titanium metallate and mixtures thereof, the metallates respectively having an empirical formula on an anhydrous basis of:
- ApMxZr1−xSinGeyOm (I)
- and
- ApMxTi1−xSinGeyOm (II)
- where A is an exchangeable cation selected from the group consisting of potassium ion, sodium ion, calcium ion, magnesium ion and mixtures thereof, M is at least one framework metal selected from the group consisting of hafnium (4+), tin (4+), niobium (5+), titanium (4+), cerium (4+), germanium (4+), praseodymium (4+), and terbium (4+), except that M is not titanium in formula (II), “p” has a value from about 1 to about 20, “x” has a value from zero to less than 1, “n” has a value from about 0 to about 12, “y” has a value from 0 to about 12, “m” has a value from about 3 to about 36 and 1≦n+y≦12.
Dependencies are inferred from the claim text.