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US 6,331,636 B1Granted
Therapeutically useful 2-aminotetralin derivatives
AssigneeThe Upjohn Company
InventorsArthur G. Romero, William H. Darlington
Life of this patent
Estimating the term…
Abstract
This invention is therapeutically useful 2-aminotetralins and pharmaceutically acceptable acid addition salts thereof of the formula These compounds are useful to treat central nervous system disorders, hypertension, diabetes, sexual impotency and to control appetite.
Claims6
A compound having the formula
- wherein,
- R1 is from the group —(CO)het and het wherein het is a five atom heterocyclic aromatic ring containing nitrogen, carbon, or optionally containing an additional heteroatom oxygen;
- R2 and R3 is independently selected from
- (a) hydrogen
- (b) C1-8 alkyl
- (c) C2-8 alkenyl
- (d) C2-8 alkynyl
- (e) (CH2)m—C3-8 cycloalkyl
- (f) (CH2)m—C3-8cycloalkenyl
- (g) (C2)m-aryl
- (h) trimethylsilylmethyl
- (i) allyl
- R4 and R5 are independently
- (a) hydrogen
- (b) C1-8 alkyl
- (c) C2-8 alkenyl
- (d) C2-8 alkynyl
- (e) (CH2)m—C3-8cycloalkyl
- (f) (CH2)m—C3-8cycloalkenyl
- (g) (CH2)m-aryl
- (h) (CH2)m—CO2R6
- (i) (CH2)m—OR6
- wherein,
- R6 is hydrogen, C1-4 alkyl or aryl,
- m is 0-4,
- or a pharmaceutically acceptable addition salt thereof.
23 more elements
A compound according to claim 1, 8-(oxazol-5-yl)-1,2,3,4-tetrahydro-2,N,N-di-n-propylaminonaphthalene and the hydrochloride thereof.
Dependencies are inferred from the claim text.