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US 6,330,106 B1Granted
Tissue specimen holder
AssigneeLucid, Inc.
InventorsRoger J. Greenwald, James M. Zavislan
Life of this patent
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AssigneeLucid, Inc.
InventorsRoger J. Greenwald, James M. Zavislan
Estimating the term…
A tray or holder for tissue specimens, especially of excised tissue, such as biopsied specimens, is used with a confocal imaging system, especially a laser scanning confocal microscope system. The tray may be disposable after imaging of the specimen carried therein or may archive the specimen. A window supports the specimen. Clamps mounted inside the tray restrain the tissue. A compliant bag is mounted outside the tray on one side of a window of the tray on which the specimen is disposed. During imaging the specimen is immersed in a liquid contained in the tray having an index of refraction which closely matches the index of refraction of the tissue. The bag also contains an index matching liquid preferably having the same index as the liquid in the tray. A stabilizing plate is attached to a surface of the bag which faces the window. Selecting an immersion liquid, which equals the refractive index of the near surface tissues, minimizes wavefront distortion which may result from an effectively corrugated surface of the specimen.
A specimen holder which comprises a container providing a surface on which a tissue specimen is disposed, a window in said container presenting at least part of said surface through which an optical beam propagates for imaging a section of the specimen or a surface of the specimen, means for clamping the specimen upon said window, a compliant bag attached opposite to the surface on which the specimen is disposed, an immersion medium having an index of refraction matched to the index of refraction of the specimen in said tray encompassing the specimen, and a coupling medium in said bag.
A specimen holder which comprises a container providing a surface on which a tissue specimen is disposed, a window in said container presenting at least part of said surface through which an optical beam propagates for imaging a section of the specimen or a surface of the specimen, a compliant bag attached opposite to the surface on which the specimen is disposed, an immersion medium having an index of refraction matched to the index of refraction of the specimen in said tray encompassing the specimen, and a coupling medium in said bag, wherein the container has an openable port through which a liquid medium flows either for the container into the bag or from the bag into the container to provide the immersion medium and the coupling medium.
A system for imaging a tissue specimen comprising:
A system for imaging a tissue specimen comprising:
A method for imaging excised tissue comprising the steps of:
Dependencies are inferred from the claim text.