Humanized antibodies to γ-interferon
AssigneeProtein Design Labs, Inc.
InventorsMaximiliano Vasquez, Nicholas F. Landolfi, Naoya Tsurushita, Cary L. Queen
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Abstract
The invention provides humanized immunoglobulins that bind to and neutralize γ-interferon. The antibodies are useful for treatment of diseases of the immune system, particularly autoimmune diseases.
Claims8
A humanized immunoglobulin, which is a humanized version of the mouse AF2 immunoglobulin having a light chain variable region designated SEQ ID No:2 and a heavy chain variable region designated SEQ ID No:4, the humanized immunoglobulin comprising humanized heavy and light chains, provided that position 11 according to the Kabat numbering system of the humanized heavy chain variable region framework is occupied by the amino acid present in the equivalent position of the mouse AF2 heavy chain variable region framework, wherein the humanized immunoglobulin specifically binds to human γ-IFN with an affinity constant within four-fold of the affinity of the mouse AF2 antibody.
A humanized immunoglobulin comprising a mature heavy chain variable region designated SEQ ID No:6 and a mature light chain variable region designated SEQ ID No:8.
Dependencies are inferred from the claim text.