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US 6,326,507 B1Granted
Therapeutic compounds and methods of use
AssigneeTrustees of Dartmouth College
InventorsGordon W. Gribble, Tadashi Honda, Michael B. Sporn, Nanjoo Suh
Life of this patent
Estimating the term…
Abstract
Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis.
Claims13
A compound having the formula:
- wherein either A or B is a double bond, and when A is a double bond, C11 has substituted thereon ═X which is an organic or inorganic moiety, and when B is a double bond, C12 has substituted thereon ═X which is an organic or inorganic moiety;
- R1 is an organic or inorganic moiety which may be substituted anywhere on the six-membered ring denoted by positions 1 through 10;
- R2 and R3 are hydrogen or organic or inorganic moieties, wherein an R2 group may be substituted anywhere on the structure represented in formula (I);
- and n is a number from 0 to 100.
1 more element
A triterpenoid compound effective for inhibiting IFN-γ-induced NO production in macrophages, said compound having an IC50 value of at least less than 0.6 μM.
A compound having the formula:
- wherein either A or B is a single or double bond and C11 or C12 have substituted thereon ═X which is an organic or inorganic moiety;
- R1 is an organic or inorganic moiety which may be substituted anywhere on the six-membered ring denoted by positions 1 through 10;
- R2 and R3 are hydrogen or organic or inorganic moieties, wherein an R2 group may be substituted anywhere on the structure represented in the formula;
- and n is a number from 0 to 100.
1 more element
Dependencies are inferred from the claim text.