Modulation of apoptosis with bid
AssigneeWashington University
InventorsAtan Gross, Stanley J. Korsmeyer
Life of this patent
Estimating the term…
Abstract
A novel p15 BID polypeptide having cell death agonist activity is disclosed. The p15 BID polypeptide is produced by caspase-cleavage of BID in cells undergoing cell death mediated by TNF or FAS receptors. The p15 BID is useful in methods for modulating death of a target cell which comprise treating the cell with p15 BID. Methods for inhibiting cell death are also described which involve treating a target cell with a mutant p15 BID lacking cell death agonist activity.
Claims6
An isolated and purified BID polypeptide fragment comprising a p15 BID polypeptide which has cell death activity wherein said fragment does not include full-length BID.
Dependencies are inferred from the claim text.