Nanoelectrode arrays
AssigneeProtiveris, Inc.
InventorJohn P. Peeters
Life of this patent
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Abstract
An array of electrodes at the atomic or nano scale (nanoelectrodes) is built on a chip. The spatial distribution, height, width and electrochemical composition of the nanoelectrodes is varied, such that protein-specific electronic receptors are built directly on the chip with the nanoelectrodes without the use of any specific binding agents or molecules. Because of their size, a very large number of different receptors can be built as arrays on a single chip. The chip can be used to detect, characterize and quantify single molecules in solution such as individual proteins, complex protein mixtures, DNA or other molecules.
Claims60
A sensor for detecting a biological molecule, said sensor comprising:
- a microcantilever,
- wherein at least one electrode comprises a height and width and length disposed on the microcantilever, wherein the at least one electrode disposed on the microcantilever is adapted to interact with and bind to a concentration of a biological molecule;
- and further comprising at least one from the group consisting of a capacitive means, an electron tunneling means, a laser means, a piezoresistive means, a piezoelectric means, a resonance frequency shift means and a x-y positional fluorescence means for detecting the concentration of the biological molecule adapted to bind to the at least one electrode, and wherein the microcantilever has a plurality of electrodes disposed thereon forming a cluster, each electrode having varying dimensions adapted to bind the cluster with biological molecules and for detecting concentrations thereof.
A sensor comprising:
- a base;
- a microcantilever integrally attached to the base;
- and
- at least one electrode disposed on the microcantilever, wherein the electrode extends from a principal surface of the microcantilever a distance of from about 2 Angstroms to about 5 nanometers, the electrode having a width of from about 2 Angstroms to about 5 nanometers.
A method for producing a sensor comprising:
- providing a microcantilever, the microcantilever having at least one electrode disposed on the microcantilever, wherein the electrode extents from a principal surface of the microcantilever a distance of from about 2 Angstroms to about 5 nanometers, and a width of from about 2 Angstroms to about 5 manometers.
Dependencies are inferred from the claim text.