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US 6,324,424 B1Granted
Reduction of skin irritation during electrotransport delivery
AssigneeAlza Corporation
InventorsPhilip W. Ledger, Michel J. N. Cormier, Patricia S. Campbell
Life of this patent
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Abstract
The invention is directed to a composition and product for use in an electrotransport device. The composition includes an ionized drug, an anti-inflammatory agent and a solvent. Preferably, the anti-inflammatory agent is hydrocortisone or esters thereof, and the solvent is water and a material such as an alcohol, a glycol, a glycerol, a cyclodextrin, a nonionic surfactant and/or mixtures thereof.
Claims23
An electrotransport donor reservoir composition, comprising:
- a therapeutic amount of an ionized drug and a skin irritation-reducing amount of an uncharged anti-inflammatory agent, wherein the drug and anti-inflammatory agent are different from one another, the drug and the anti-inflammatory agent being dissolved in a liquid solvent comprising water and a material selected from the group consisting of alcohols, glycols, glycerols, cyclodextrins, non-ionic surfactants and mixtures thereof.
A method of making an electrotransport donor reservoir comprising:
- forming a solution of a therapeutically effective amount of an ionized drug and a skin irritation-reducing amount of an uncharged anti-inflammatory agent, wherein the drug and anti-inflammatory agent are different from one another, by dissolving the drug and the anti-inflammatory agent in a liquid solvent comprising water and a material selected from the group consisting of alcohols, glycols, glycerols, cyclodextrins, non-ionic surfactants and mixtures thereof, and
- adding said solution to a polymeric matrix to form said reservoir.
Dependencies are inferred from the claim text.