Use of sulfamate derivatives for treating impulse control disorders
AssigneeUniversity of Cincinnati
InventorSusan McElroy
Life of this patent
Estimating the term…
Abstract
Impulse Control Disorders (ICD's) are characterized by harmful behaviors performed in response to irresistible impulses. The essential feature of an ICD is the failure to resist an impulse, drive, or temptation and to perform an act that is harmful to the person or to others. The present invention comprises methods for the treatment or prevention of ICD's using a class of sulfamates of the following formula: wherein X is CH2 or oxygen, and R1, R2, R3, R4 and R5 are as herein defined. Further, pharmaceutical compositions containing a compound of formula (I) as well as methods for their use and intermediates form part of the present invention are also disclosed.
Claims16
A method for treating an Impulse Control Disorder comprising administering to a mammal afflicted with such condition a therapeutically effective amount for treating such condition of a compound of the formula I:
- wherein
- X is CH2 or oxygen;
- R1 is hydrogen or alkyl;
- and
- R2, R3, R4 and R5 are independently hydrogen or lower alkyl and, when X is CH2, R4 and R5 may be alkene groups joined to form a benzene ring and, when X is oxygen, R2 and R3 and/or R4 and R5 together may be a methylenedioxy group of the follow formula (II):
- wherein
- R6 and R7 are the same or different and are hydrogen, lower alkyl or are alkyl and are joined to form a cyclopentyl or cyclohexyl ring;
- wherein the Impulse Control Disorder is selected from the group consisting of intermittent explosive disorder (ED), kleptomania, pathological gambling, pyromania, trichotillomania, compulsive buying or shopping, repetitive self-mutilation, nonparaphilic sexual addictions, severe nail biting, compulsive skin picking, personality disorders with impulsive features, attention deficit/hyperactivity disorder, Binge Eating Disorder, bulimia nervosa, anorexia nervosa with binge eating and substance use disorders.
A method for treating an Impulse Control Disorder comprising administering to a mammal afflicted with such condition a therapeutically effective amount for treating such condition of a compound of the formula I:
- wherein
- X is CH2 or oxygen;
- R1 is hydrogen or alkyl;
- and
- R2, R3, R4 and R5 are independently hydrogen or lower alkyl and, when X is CH2, R4 and R5 may be alkene groups joined to form a benzene ring and, when X is oxygen, R2 and R3 and/or R4 and R5 together may be a methylenedioxy group of the following formula (II):
- wherein
- R6 and R7 are the same or different and are hydrogen, lower alkyl or are alkyl and are joined to form a cyclopentyl or cyclohexyl ring;
- wherein the Impulse Control Disorder is selected from the group consisting of intermittent explosive disorder (IED), kleptomania, pathological gambling, pyromania, trichotillomania, compulsive buying or shopping, repetitive self-mutilation, nonparaphilic sexual addictions, severe nail biting, compulsive skin picking, personality disorders with impulsive features, attention deficit/hyperactivity disorder, Binge Eating Disorder, anorexia nervosa with binge eating and substance use disorders.
A method for treating an Impulse Control Disorder comprising administering to a mammal afflicted with such condition a therapeutically effective amount for treating such condition of a compound of the formula I:
- wherein
- X is CH2or oxygen;
- R1 is hydrogen or alkyl;
- and
- R2, R3, R4 and R5 are independently hydrogen or lower alkyl and, when X is CH2, R4 and R5 may be alkene groups joined to form a benzene ring and, when X is oxygen, R2 and R3 and/or R4 and R5 together may be a methylenedioxy group of the following formula (II):
- wherein
- R6 and R7 are the same or different and are hydrogen, lower alkyl or are alkyl and are joined to form a cyclopentyl or cyclohexyl ring;
- wherein the Impulse Control Disorder is bulimia nervosa.
A method for treating an Impulse Control Disorder characterized by binge eating, wherein the Impulse Control Disorder is selected from the group consisting of Binge Eating Disorder, Bulimia Nervosa and Anorexia Nervosa with Binge Eating, said method comprising administering to a human afflicted with such a disorder, a therapeutically effective amount of topiramate in combination with one or more drug compounds selected from the group consisting of serotonin re-uptake inhibitors, antidepressants, psychostimulants, orlistat, and sibutramine.
A method for treating an Impulse Control Disorder characterized by binge eating, wherein the Impulse Control Disorder is selected from the group consisting of Binge Eating Disorder, Bulimia Nervosa and Anorexia Nervosa with Binge Eating, said method comprising administering to a human afflicted with such a disorder, a therapeutically effective amount of topiramate in combination with a serotonin re-uptake inhibitor.
Dependencies are inferred from the claim text.