Beta-lipotropin methods
AssigneeEli Lilly and Company
InventorsJohn Edward Hale, Mark Louis Heiman, Brigitte Elisabeth Schoner, William Francis Heath, Jr.
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Abstract
The invention provides isolated nucleic acids, vectors, transformed host cells, analogs, functional fragments, and fusion proteins, related to beta-lipotropin. Also provided are pharmaceutical compositions comprising beta-lipotropin or fragments and/or analogs thereof, and methods for treating diabetes and complications associated therewith by administration of an effective amount of beta-lipotropin.
Claims19
A method for treating diabetes in a mammal comprising administration of a therapeutically effective amount of a naturally-occurring mammalian beta-lipotropin.
A method for treating diabetes in a mammal comprising administration of a therapeutically effective amount of a functional fragment of a naturally-occurring mammalian beta-lipotropin wherein said fragment has the activity of lowering blood glucose.
A method for treating diabetes in a mammal comprising administration of a therapeutically effective amount of beta-lipotropin wherein said beta-lipotropin is human beta-lipotropin, having a sequence identified herein as SEQ ID NO:8.
A method for lowering blood glucose levels in a mammal by administering an effective amount of a naturally-occurring mammalian beta-lipotropin.
A method for treating hyperglycemia in a mammal in need thereof by administering an effective amount of a naturally-occurring mammalian beta-lipotropin.
A method for treating hyperinsulinemia in a mammal by administering an effective amount of a naturally-occurring mammalian beta-lipotropin.
A method for enhancing insulin sensitivity in a mammal by administering an effective amount of a naturally-occurring mammalian beta-lipotropin.
A method for treating diabetes in a mammal comprising administration of a therapeutically effective amount of beta-lipotropin wherein said beta-lipotropin is selected from the group consisting of SEQ ID NO:2, SEQ ID NO:5, SEQ ID NO:7, and SEQ ID NO:8.
A method for treating diabetes comprising administration of a therapeutically effective amount of at least one peptide selected from the group consisting of SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, wherein said peptide has the ability to lower blood glucose in vivo.
A method, for treating diabetes comprising administration of a therapeutically effective amount of a peptide having the ability to lower blood glucose in vivo, said peptide being selected from the group consisting of:
- a) SEQ ID NO:9
- b) SEQ ID NO:10
- c) SEQ ID NO:11
- d) SEQ ID NO:12
- e) SEQ ID NO:13
- f) SEQ ID NO:14
- g) SEQ ID NO:15
- h) SEQ ID NO:16
- i) SEQ ID NO:17
- j) SEQ ID NO:18
- k) SEQ ID NO:19
- l) SEQ ID NO:20
- m) SEQ ID NO:21
- n) SEQ ID NO:22
- o) SEQ ID NO:23
- p) SEQ ID NO:24
- q) SEQ ID NO:25.
A method for alleviating the symptoms of a complication associated with diabetes in a patient in need thereof comprising administration of a therapeutically effective amount of beta-lipotropin, said complication selected from the group consisting of:
- a) diabetic foot;
- b) urinary tract infection;
- and
- c) peripheral vascular disease.
A method for treating diabetes in a mammal comprising administration of a therapeutically effective amount of an functional analog of a naturally-occurring mammalian beta-lipotropin, said analog having a single amino acid substitution in SEQ ID NO:8, and wherein said analog has a biological activity selected from the group consisting of:
- a) the ability to lower blood glucose in vivo;
- b) the ability to promote glucose uptake in vivo and/or in vitro;
- and
- c) the ability to enhance insulin sensitivity.
A method for treating diabetes comprising administration of a therapeutically effective amount of at least one peptide selected from the group consisting of SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, wherein said peptide has the ability to enhance insulin sensitivity.
Dependencies are inferred from the claim text.