Synthetic biomaterial compound of calcium phosphate phases particularly adapted for supporting bone cell activity
AssigneeMillenium Biologix, Inc.
InventorsSydney M. Pugh, Timothy J. N. Smith, Michael Sayer, Sarah Dorthea Langstaff
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Abstract
The present invention is directed to a synthetic biomaterial compound based on stabilized calcium phosphates and more particularly to the molecular, structural and physical characterization of this compound. The compound comprises calcium, oxygen and phosphorous, wherein at least one of the elements is substituted with an element having an ionic radius of approximately 0.1 to 1.1 Å. The knowledge of the specific molecular and chemical properties of the compound allows for the development of several uses of the compound in various bone-related clinical conditions.
Claims28
An isolated bioresorbable biomaterial compound comprising calcium, oxygen and phosphorous, wherein a portion of at least one of said elements is substituted with an element having an ionic radius of approximately 0.1 to 0.6 Å.
A biomaterial compound comprising calcium, oxygen and phosphorous, wherein at least one of said elements is substituted with an element having an ionic radius of approximately 0.1 to 1.1 Å and wherein said compound is selected from the group consisting of Ca3(P0.750Si0.25O3.875)2 and Ca3(P0.9375Si0.0625O3.96875)2.
A biomaterial compound having the formula:
- (Ca)i{(P1−x−y−zBxCyDz)Oj}2
- wherein B, C and D are selected from those elements having an ionic radius of approximately 0.1 to 0.4 Å;
- x is greater than or equal to zero but less than 1;
- y is greater than or equal to zero but less than 1;
- z is greater than or equal to zero but less than 1;
- x+y+z is greater than zero but less than 1;
- i is greater than or equal to 2 but less than or equal to 4;
- and
- j is equal to 4−δ, where δ is greater than or equal to zero but less than or equal to 1.
Dependencies are inferred from the claim text.