Recombinant human CSF-1 dimer and compositions thereof
AssigneeChiron Corporation
InventorsRobert Halenbeck, Kirston Koths, Cynthia Cowgill, Walter J. Laird
Life of this patent
Estimating the term…
Abstract
The present invention is directed to an isolated and purified, recombinant, unglycosylated and dimeric CSF-1, the dimeric CSF-1 being biologically active and essentially endotoxin and pyrogen-free, the dimeric CSF-1 consisting essentially of two monomeric human CSF-1 subunits. The present invention is further directed to pharmaceutical compositions comprising the same.
Claims14
An isolated and purified, recombinant, unglycosylated and dimeric CSF-1, said dimeric CSF-1 being biologically active and having an endotoxin content of less than 1.0 ng/mg CSF-1 as determined by standard LAL assay, said dimeric CSF-1 consisting essentially of two monomeric human CSF-1 subunits.
A pharmaceutical composition comprising:
- (a) an isolated and purified, recombinant, unglycosylated and dimeric CSF-1, said dimeric CSF-1 being biologically active and having an endotoxin content of less than 1.0 ng/mg CSF-1 consisting essentially of two monomeric human CSF-1 subunits;
- and
- (b) a pharmaceutical excipient.
Dependencies are inferred from the claim text.