Optical imaging using time gated scattered light
AssigneeMassachusetts Institute of Technology
InventorsLev T. Perelman, Jun Wu, Yang Wang, Ramachandra Rac Dasari, Irving Itzkan, Michael S. Feld
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Abstract
The present invention relates to the use of time gated scattered light, for determining the location and composition of material within various organs of the human body. The systems and methods of the present invention provide for medical imaging in three dimensions of internal body structures for diagnostic purposes.
Claims19
A method for detecting material within tissue comprising:
- irradiating tissue with optical radiation along an optical path, the tissue having material located underneath a surface of the tissue;
- collecting flourescent optical radiation from the material;
- measuring a rising intensity distribution of the collected fluorescent optical radiation in a time interval between 0 and 1500 picoseconds after irradiation of the tissue;
- comparing the measured rising intensity distribution with a reference representation of light trajectories in the tissue;
- and
- determining the location of the material within the tissue from the comparison of the measured rising intensity distribution and the representation.
A method for detecting material within tissue comprising:
- irradiating tissue with radiation from a laser along an optical path;
- collecting scattered fluorescent radiation from the material;
- sensing a rising intensity distribution of the collected fluorescent radiation in a time interval between 0 and 500 picoseconds after irradiation of the tissue;
- analyzing the sensed rising intensity distribution;
- and
- forming a two dimensional representation of the material within the tissue from the analyzed intensity distribution.
A system for detecting material within tissue comprising:
- a laser that irradiates tissue with optical radiation along an optical path;
- a fiber optic device that delivers the radiation along the fluorescent path and that collects scattered optical radiation from the material;
- a detector that detects a rising intensity distribution of the collected fluorescent radiation in a time interval between 0 and 1500 picoseconds after irradiation of the tissue;
- and
- a computer that compares the detected rising intensity distribution with a reference representation of light trajectories in the tissue stored in a memory of the computer and that forms a two dimensional representation of the material within the tissue.
A method for detecting material within tissue comprising:
- irradiating tissue with radiation from a laser along an optical path;
- collecting scattered fluorescent or Raman radiation from the material, the scattered fluorescent or Raman radiation having a rise period and a decay period;
- sensing an intensity distribution of the collected fluorescent or Raman radiation in a time interval during the rise period;
- analyzing the sensed intensity distribution from the rise period;
- and
- forming a representation of the material within the tissue from the analyzed intensity distribution from the rise period.
Dependencies are inferred from the claim text.