Method for isolation of n-protected s-phenylcysteine
AssigneeKaneka Corporation
InventorsYasuyoshi Ueda, Hiroshi Murao, Koki Yamashita, Koichi Kinoshita
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Abstract
This invention provides a method of isolating N-protected-S-phenylcysteine (1) of high purity, expediently, efficiently and in good yield, which comprises causing said N-protected-S-phenylcysteine to be salted out in the form of a base salt in the presence of water. wherein R1 represents an amino-protecting group; R2 represents a hydrogen atom or, either independently of R1 or taken together with R1, represents an amino-protecting group.
Claims21
A method for isolation of an N-protected-S-phenylcysteine represented by the following formula (1):
- wherein R1 represents an amino-protecting group;
- R2 represents a hydrogen atom or, either independently of R1 or taken together with R1, represents an amino-protecting group,
- which comprises causing said N-protected-S-phenylcysteine to be salted out in the form of a base salt in the presence of water.
A method of preparing a mixture of an organic solvent and a free N-protected-S-phenylcysteine which comprises causing an N-protected-S-phenylcysteine represented by the following formula (1):
- wherein R1 represents an amino-protecting group;
- R2 represents a hydrogen atom or, either independently of R1 or taken together with R1, represents an amino-protecting group,
- to be salted out in the form of a base salt in the presence of water, and
- neutralizing, with an acid, the base salt of N-protected-S-phenylcysteine,
- to give the free N-protected-S-phenylcysteine and, then, mixing said free N-protected-S-phenylcysteine with an organic solvent.
Dependencies are inferred from the claim text.