Preparation of arylphosphines
AssigneeChirotech Technology Limited
InventorsStephen Benedict David Winter, Ian Campbell Lennon
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Abstract
The present invention pertains to a process for the preparation of an arylphosphine of the formula R1OC—Ar—PR2R3 wherein Ar is aryl or heteroaryl; R1 is an alkoxy or amine group; and R2 and R3 are each any organic group; and each of the respective groups may optionally be substituted with any non-interfering group; which comprises the reaction of a sulfonyloxy compound of the formula R1OC—Ar—OSO2R4 wherein R4 is alkyl, haloalkyl, perhaloalkyl, aryl, aralkyl or alkaryl, with a phosphine of the formula HPR2R3, in a solvent and in the presence of a palladium catalyst and a base. The arylphosphine can then readily be converted to a chiral phosphine ligand.
Claims29
A process for preparation of an arylphosphine of the formula
- R1OC—Ar—PR2R3
- wherein Ar is aryl or heteroaryl;
- R1 is an alkoxy or amine group, and R2 and R3 are each any organic group;
- and each of the respective groups may optionally be substituted with any non-interfering group;
- which comprises the reaction of a sulfonyloxy compound of the formula
- R1OC—Ar—OSO2R4
- wherein R4 is alkyl, haloalkyl, perhaloalkyl, aryl, aralkyl or alkaryl, with a secondary or primary phosphine of the formula HPR2R3, in a solvent and in the presence of a palladium catalyst and a base.
Dependencies are inferred from the claim text.