Process for the preparation of leukotriene antagonists
AssigneeMerck & Co., Inc.
InventorsMahadevan Bhupathy, Daniel R. Sidler, James M. McNamara, Ralph P. Volante, James Bergan
Life of this patent
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Abstract
The present invention relates to a process for the preparation of a compound of formula (I) or a sodium salt thereof wherein HET is 7-chloroquinolin-2-yl or 6,7-difluoroquinolin-2-yl, which comprises: reacting the dilithium dianion of 1-(mercapto-methyl)cyclopropaneacetic acid with a compound of formula (II) wherein HET is as defined above and L is arylsulfonyl or alkylsulfonyl. The invention further provides the dicyclohexylamine salt of a compound of formula (I).
Claims5
Crystalline 2-(2-(3(S)-(3-(2-(7-chloro-2-quinolinyl)-ethenyl)phenyl)-3-methanesulfonyloxypropyl)phenyl)-2-propanol of the formula
- wherein HET is 7-chloro-2-quinolinyl.
Crystalline sodium 1-(((1(R)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetate.
Crystalline dicyclohexylamine salt of 1-(((1(R)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetic acid having an x-ray powder diffraction pattern substantially similar to that shown in FIG. 2.
Crystalline dicyclohexylamine salt of 1-(((1(R)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetic acid having an x-ray powder diffraction pattern substantially similar to that shown in FIG. 6.
Dependencies are inferred from the claim text.